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In one embodiment, the present invention is directed toward a method for identifying a gene or gene product essential for proliferation or pathogenicity of a prokaryotic organism comprising placing a nucleic acid comprising a nucleotide sequence encoding a putative essential gene under control of at least one tet operator, introducing an expression vector comprising a nucleotide sequence encoding a modified tetracycline repressor into the a prokaryotic organism, expressing the modified tetracycline repressor polypeptide, contacting the organism with a concentration of tetracycline or tetracycline analog sufficient to repress the expression level of gene product, and determining the viability of the organism!
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